Andrea J. Sant obtained her PhD from Washington University in St. Louis, with a focus on immunogenetics, and then completed post-doctoral training in the Laboratory of Immunology with Ron Germain at NIH, studying MHC class II biochemistry. After a 12-year faculty position at the University of Chicago, where she studied the cell biology of MHC class II trafficking and CD4 T cell immunodominance, she moved to the University of Rochester in 2002. Here, she linked the biochemical features of MHC:peptide complexes that control CD4 preferences in CD4 T cell specificity to their impact on HLA-DM editing of peptides that ultimately control recognition of peptide epitopes by CD4 T cells. Her recent focus in the last 15 years has been on CD4 T cell responses to influenza virus and SARS-CoV-2 infection and vaccination, studied in both animal models and human subjects.
Andrea J. Sant, PhD
Professor, Department of Microbiology and Immunology, Center for Vaccine Biology and Immunology (SMD) at the University of Rochester Medical Center
