Xiaoyang Wu, PhD

Given their pivotal role in tissue homeostasis and regenerative medicine, somatic/adult stem cells are of tremendous interest to both biomedical research field and the public. Skin and its appendages provide a protective barrier that keeps harmful microbes out and essential body fluids in. To perform these functions while confronting the physicochemical traumas from the outside world, human skin must undergo rejuvenation through homeostasis and wound repair. Both processes rely on the essential activities of skin somatic stem cells, including the activation and migration of epidermal stem cells upon wounding, as well as the delicate balance of epidermal stem cell proliferation, self-renewal and differentiation during tissue homeostasis. Understanding the underlying mechanisms is important, because dysregulation of these processes leads to many skin diseases including cancers. Research in my laboratory is dedicated to understanding the dynamics, signaling, and clinical applications of epidermal stem cells. Particularly, we are interested in three fundamental questions in this field: 1) regenerative medicine and tissue engineering with epidermal stem cells; 2) migration and cytoskeletal dynamics of epidermal stem/progenitor cells; and 3) molecular mechanisms controlling stemness and differentiation of epidermal stem cells.

Cornell University
Ithaca, NY
Ph.D. - Pharmacology
2006

Nanjing University
Nanjing, China
MS - Molecular Biology
2000

Nanjing University
Nanjing, China
BS - Biochemistry
1997

Epidermal Stem Cells in Skin Wound Healing.
Li Y, Zhang J, Yue J, Gou X, Wu X. Epidermal Stem Cells in Skin Wound Healing. Adv Wound Care (New Rochelle). 2017 Sep 01; 6(9):297-307.
PMID: 28894637

Engineered Epidermal Progenitor Cells Can Correct Diet-Induced Obesity and Diabetes.
Yue J, Gou X, Li Y, Wicksteed B, Wu X. Engineered Epidermal Progenitor Cells Can Correct Diet-Induced Obesity and Diabetes. Cell Stem Cell. 2017 08 03; 21(2):256-263.e4.
PMID: 28777946

Spectraplakin family proteins - cytoskeletal crosslinkers with versatile roles.
Zhang J, Yue J, Wu X. Spectraplakin family proteins - cytoskeletal crosslinkers with versatile roles. J Cell Sci. 2017 Aug 01; 130(15):2447-2457.
PMID: 28679697

Molecular and cytoskeletal regulations in epidermal development.
Lee J, Lee P, Wu X. Molecular and cytoskeletal regulations in epidermal development. Semin Cell Dev Biol. 2017 09; 69:18-25.
PMID: 28577925

ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics.
Ma Y, Yue J, Zhang Y, Shi C, Odenwald M, Liang WG, Wei Q, Goel A, Gou X, Zhang J, Chen SY, Tang WJ, Turner JR, Yang F, Liang H, Qin H, Wu X. ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Nat Commun. 2017 05 25; 8:15375.
PMID: 28541346

Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis.
Lee P, Jiang S, Li Y, Yue J, Gou X, Chen SY, Zhao Y, Schober M, Tan M, Wu X. Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis. EMBO J. 2017 07 03; 36(13):1963-1980.
PMID: 28507225

In vivo epidermal migration requires focal adhesion targeting of ACF7.
Yue J, Zhang Y, Liang WG, Gou X, Lee P, Liu H, Lyu W, Tang WJ, Chen SY, Yang F, Liang H, Wu X. In vivo epidermal migration requires focal adhesion targeting of ACF7. Nat Commun. 2016 05 24; 7:11692.
PMID: 27216888

Regulation of Focal Adhesion Dynamics and Cell Motility by the EB2 and Hax1 Protein Complex.
Liu H, Yue J, Huang H, Gou X, Chen SY, Zhao Y, Wu X. Regulation of Focal Adhesion Dynamics and Cell Motility by the EB2 and Hax1 Protein Complex. J Biol Chem. 2015 Dec 25; 290(52):30771-82.
PMID: 26527684

Ultraviolet B Inhibits Skin Wound Healing by Affecting Focal Adhesion Dynamics.
Liu H, Yue J, Lei Q, Gou X, Chen SY, He YY, Wu X. Ultraviolet B Inhibits Skin Wound Healing by Affecting Focal Adhesion Dynamics. Photochem Photobiol. 2015 Jul-Aug; 91(4):909-16.
PMID: 25918970

Microtubules regulate focal adhesion dynamics through MAP4K4.
Yue J, Xie M, Gou X, Lee P, Schneider MD, Wu X. Microtubules regulate focal adhesion dynamics through MAP4K4. Dev Cell. 2014 Dec 08; 31(5):572-85.
PMID: 25490267

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V scholar award, the V foundation
2012

ACS (American Cancer Society) research scholar award
2012

The Cancer Research Foundation Young Investigator Award
2011

The Jane Coffin Childs Memorial Fund for Medical Research
2008

AACR-Anna D Barker Fellowship in Basic Cancer Research
2007