Xiaoyang Wu, Ph.D.


Selected Publications:

 1. Development of an intrinsic skin sensor for blood glucose level with CRISPR-mediated genome editing in epidermal stem cells. Yue J, Gou X, Wu X. Under review. (Media report: MIT technology review)

2. Protection against cocaine-seeking and acute overdose by genome-edited epidermal stem cells. Li Y, Kong Q, Yue J, Gou X, Xu M, Wu X. Nature Biomedical Engineering, in press.

3. Review article: Epidermal stem cells in skin wound healing. Li C, Zhang J, Yue J, Gou X, Wu X. Advances in Wound Care, 2017 Sep 1. PMID: 28894637.

4. Engineered epidermal progenitor cells can correct diet-induced obesity and diabetes. Yue J, Gou X, Li Y, Wicksteed B, Wu X. Cell Stem Cell, 2017 Aug 3. PMID: 28777946. Preview: Engineering skin with skinny genes. Bottcher A, Lickert H, Tschop M. Cell Stem Cell, 2017 Aug 3. (Media reports: CNBC, ScienceDaily, The Scientist, New Scientist, Genengnews, Healthday, Medical Xpress, Stem Cells Daily, ResearchGate, bionews.org, newsmax, medicalresearch.com, medicalnewstoday.com, Tech Times, Engadget, Futurism.com, Alnmag, medgadget, ictandhealth.com, bigthink.com, digitaltrends.com, stemcelltherapy, themerkle.com, Scienxx.de (Germany), India Times (India), Deccan Chronical (India), the Statesman (India), SINC la ciencia es (Spain), El Pais (Spain), Irish Independent (Ireland), Correio Braziliense (Brazil), Cultura Colectiva (Mexico), diabetes.co.uk (United Kingdom), et al.)

5. Review article: Spectraplakin family proteins: cytoskeletal crosslinkers with versatile roles. Zhang J, Yue J, Wu X. Journal of Cell Science, 2017 Aug 1. PMID: 28679697.

6. Review article: molecular and cytoskeletal regulations in epidermal development. Lee J, Lee P, Wu X. Semin Cell Dev Biol, 2017 May 31. PMID: 28577925.

7. Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis. Lee P, Jiang S, Li Y, Yue J, Gou X, Chen SY, Zhao Y, Schober M, Tan M, Wu X. EMBO Journal, 2017 May 15. PMID: 28507225.

8. ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Ma Y, Yue J, Zhang Y, Shi C, Odenwald M, Liang W, Wei Q, Goel A, Gou X, Zhang J, Chen SY, Tang WJ, Turner JR, Yang F, Liang H, Qin H, Wu X. Nature Communications, 2017 May 25. PMID: 28541346.

9. In vivo epidermal migration requires focal adhesion targeting of ACF7. Yue J, Zhang Y, Liang W, Gou X, Lee P, Liu H, Lyu W, Tang WJ, Chen SY, Yang F, Liang H, Wu X. Nature Communications, 2016 May 24; 7:11692. PMID: 27216888.

10. Regulation of focal adhesion dynamics and cell motility by EB2 and Hax1 complex. Liu H, Yue J, Huang H, Gou X, Chen SY, Zhao Y, Wu X. Journal of Biological Chemistry, 2015 Nov 2. PMID: 26527684.

11. Review article: modifications of human serum albumin and their binding effect. Lee P, Wu X. Curr Pharm Des, 2015; 21 (14): 1862-5. PMID: 25732553.

12. Ultraviolet B inhibits skin wound healing by affecting focal adhesion dynamics. Liu H, Yue J, Lei Q, Gou X, Chen SY, He YY, Wu X. Photochem Photobiol, 2015 Jul-Aug; 91 (4): 909-16. PMID: 25918970.

13. Microtubules regulate focal adhesion dynamics through MAP4K4. Yue J, Xie M, Gou X, Lee P, Schneider MD, Wu X. Developmental Cell, 2014 Dec8; 31 (5): 572-85. PMID: 25490267.

14. Review article: Spectraplakins: master orchestrators of cytoskeletal dynamics. Suozzi K, Wu X, Fuchs E. Journal of Cell Biology, 2012 May 14; 197 (4): 465-75. PMCID: PMC3352950.

15. Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. Wu X, Shen QT, Oristian DS, Lu CP, Zheng QS, Wang HW, and Fuchs E. Cell, 2011 Feb 4; 144(3): 341-52. PMCID: PMC3050560.

16. ACF7 regulates cytoskeletal-focal adhesion dynamics and cell migration and has ATPase activity. Wu X, Kodama A, Fuchs E. Cell, (cover article), 2008 Oct 3; 135(1): 137-48. PMCID: PMC2703712.

17. Regulation of RNA polymerase II-dependent transcription by N-WASP and its nuclear binding partners. Wu X, Yoo YD, Guan JL, Nature Cell Biology, 2006 Jul; 8(7):756-63.

18. FAK-mediated Src phosphorylation of Endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Wu X, Gan B, Yoo YD, Guan JL. Developmental Cell, 2005 Aug; 9(2):185-96.

19. Focal adhesion kinase regulation of N-WASP subcellular localization and function. Wu X, Suetsugu S, Cooper LA, Takenawa T, Guan JL. Journal of Biological Chemistry, 2004 Mar 5; 279(10): 9565-76.