Wei-Jen Tang, Ph.D.


Complete List of Published Work in MyBibliography:

Tang W.-J. (2016) Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus. Trends Endocrinol Metab 27:24-34.

Liang WG, Triandafillou CG, Huang T-Y, Zulueta MML, Banerjee S, Dinner AR, Hung S-C, & Tang WJ (2016) Structural basis for oligomerization and glycosaminoglycan-binding of CCL5 and CCL3. Proc Natl Acad Sci USA 113:5000-5005.

King, J.V., Liang, W.G., Scherpelz, K.P., Schilling, A.B., Meredith, S.C., and Tang, W.-J. (2014) Molecular basis of substrate recognition and degradation by human presequence protease. Structure 22:996-1007.

McCord L.A., Liang, W.G., Dowdell, E., Kalas, V., Hoey, R.J., Koide, A., Koide, S., and Tang, W.-J. (2013) Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme Proc. Natl. Acad. Sci. USA 110(34):13827-32.

Ren, M., Guo, Q., Guo, L., Lenz, M., Qian, F., Koenen, R.R., Xu, H., Schilling, A.B., Weber, C., Ye, R.D., Dinner, A.R., and Tang, W.-J. (2010) Polymerization of MIP-1 chemokine (CCL-3 and CCL-4) and clearance of MIP-1 by insulin degrading enzyme. EMBO J. 29:3952-3966.

Manolopoulou, M., Guo, Q., Malito, E. Schilling, A, and Tang, W.J. (2009) Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin degrading enzyme. J Biol Chem 284:14177-88.

Shen, Y., Joachimiak, A., Rosner, M.R., and Tang, W.-J. (2006) Structures of human insulin degrading enzyme reveal a new substrate recognition mechanism. Nature 443:870-874. (Highlighted in N&V Nature 443:761, 2006)

Shen, Y.-Q., Zhukovskaya, N.L., Zimmer, M.I., Soelaiman, S., Wang, C.R., Gibbs, C.S., Tang, W.-J. (2004) Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Proc. Natl. Acad. Sci. U.S.A. 101:3242-3247.

Drum, C.L., Yan, S.-Z., Bard, J., Shen, Y.-Q., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A., and Tang, W.-J. (2002) Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature 415:396-402. (Highlighted in N&V Nature 415: 373, 2002; N &V Nature Structure Biology 9:156, 2002; Minireview Cell 108:739, 2002)

Tang, W.-J. and Gilman, A.G. (1995) Forskolin and Gsa sensitive soluble adenylyl cyclase.  Science 268:1769-1772.

Tang, W.-J. and Gilman, A. G. (1991) Type-specific regulation of adenylyl cyclase by G protein __ subunits. Science 254:1500-1503.