The Yang Lab is battling on the frontiers of precision medicine. We focus mostly on human cancer, and are also interested in non-cancer human diseases as well. We develop new computational methods to integrate the large scale genomic, transcriptomic, epigenetic and clinical data to understand the mechanisms of pathogenesis, to discover new drug targets, and eventually, to help patients.
Harvard Medical School
Boston, MA
Postdoc - Biomedical Informatics
University of Georgia
Athens, GA
PhD - Genetics
Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors.
Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors. Clin Cancer Res. 2024 Dec 02; 30(23):5445-5458.
PMID: 39321214
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer.
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer. Nat Cancer. 2024 Dec; 5(12):1885-1901.
PMID: 39558146
HYENA detects oncogenes activated by distal enhancers in cancer.
HYENA detects oncogenes activated by distal enhancers in cancer. Nucleic Acids Res. 2024 Sep 09; 52(16):e77.
PMID: 39051548
Somatic structural variation signatures in pediatric brain tumors.
Somatic structural variation signatures in pediatric brain tumors. Cell Rep. 2023 10 31; 42(10):113276.
PMID: 37851574
SFyNCS detects oncogenic fusions involving non-coding sequences in cancer.
SFyNCS detects oncogenic fusions involving non-coding sequences in cancer. Nucleic Acids Res. 2023 Oct 13; 51(18):e96.
PMID: 37638762
Starfish infers signatures of complex genomic rearrangements across human cancers.
Starfish infers signatures of complex genomic rearrangements across human cancers. Nat Cancer. 2022 10; 3(10):1247-1259.
PMID: 35835961
A functional genomic approach to actionable gene fusions for precision oncology.
A functional genomic approach to actionable gene fusions for precision oncology. Sci Adv. 2022 02 11; 8(6):eabm2382.
PMID: 35138907
Meerkat: An Algorithm to Reliably Identify Structural Variations and Predict Their Forming Mechanisms.
Meerkat: An Algorithm to Reliably Identify Structural Variations and Predict Their Forming Mechanisms. Methods Mol Biol. 2022; 2493:107-135.
PMID: 35751812
Whole-genome characterization of lung adenocarcinomas lacking the RTK/RAS/RAF pathway.
Whole-genome characterization of lung adenocarcinomas lacking the RTK/RAS/RAF pathway. Cell Rep. 2021 02 02; 34(5):108707.
PMID: 33535033
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nat Commun. 2020 09 21; 11(1):4748.
PMID: 32958763