Michelle Le Beau, Ph.D.


Lai, F., Godley, L.A., Joslin, J., Fernald, A.A., Liu, J., Espinosa, R. 3rd, Zhao, N., Pamintuan, L., Till, B.G., Le Beau, M.M. Transcript map and comparative analysis of the 1.5 Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). Genomics 71:235-245, 2001.

Corbin, S., Neilly, M.E., Espinosa, R. 3rd, Davis, E.M., McKeithan, T.W., Le Beau, M.M. Identification of unstable sequences within the common fragile site at 3p14.2: Implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors. Cancer Res 62:3477-3484, 2002.

Qian, Z., Fernald, A.A., Godley, L.A., Larson, R.A., Le Beau, M.M. Expression profiling of CD34+ hematopoietic stem/progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia. Proc Natl Acad Sci USA 99:14925-14930, 2002.

Le Beau, M.M., Davis, E.M., Patel, B., Phan, V.T., Sohal, J., Kogan, S.C. Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia. Blood 102:1072-1074, 2003.

Smith, S.M., Le Beau, M.M., Huo, D., Karrison, T., Sobecks, R.M., Anastasi, J., Vardiman, J.W., Rowley, J.D., Larson, R.A. Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood, 102:43-52, 2003.

Lucas I, Palakodeti A, Jiang Y, Young DJ, Jiang N, Fernald AA, Le Beau MM.  High throughput mapping of origins of replication in human cells. EMBO Rep 8:770-777, 2007.

Joslin JM, Fernald AA, Tennant TR, Davis EM, Kogan SC, Anastasi J, Crispino JD, Le Beau MM.  Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders.  Blood 110:719-726, 2007.

Qian Z, Chen L, Fernald AA, Williams BO, Le Beau MM. A critical role for Apc in hematopoietic stem and progenitor cell survival. J Exp Med 205:2163-75, 2008.

Shannon KM, Le Beau MM. Cancer: hay in a haystack.  Nature 451:252-253, 2008.

Jiang Y, Lucas I, Young DJ, Davis EM, Karrison T, Rest JS, Le Beau MM. Common fragile sites are characterized by histone hypoacetylation.  Hum Mol Genet 18:4501-4512, 2009.   
Wang J, Fernald AA, Anastasi J, Le Beau MM, Qian Z. Haploinsufficiency of Apc leads to ineffective hematopoiesis. Blood 115:3481-3488, 2010.

Palakodeti A, Lucas I, Jiang Y, Young DJ, Fernald AA, Karrison T, Le Beau MM.  Impaired replication dynamics at the FRA3B common fragile site.  Hum Mol Genet 19:99-110, 2010. 

Stoddart A, Tennant TR, Fernald AA, Anastasi J, Brodsky FM, Le Beau MM. The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.  Oncogene. 2011 Jun 27. doi: 10.1038/onc.2011.251.
Odenike O, Le Beau MM.  The dawn of the molecular era of the myelodysplastic syndromes.   N Engl J Med 364:2545-6, 2011.