Anning Lin, MD PhD

Signaling mechanism in inflammation, cancer and neuronal degenerative disease



My laboratory has a long-standing interest in understanding how the intracellular signaling network is integrated in response to a variety of extracellular signals, thereby controlling proliferation, programmed cell death and transformation. Our recent work focuses on elucidating the signaling mechanism in inflammatory disease, such as severe sepsis and colitis-associated cancer, and neuronal degenerative disease like Alzheimer’s disease, using a multifaceted experimental approach involving biochemistry, molecular cell biology, proteomics, computational modeling and animal models. Our long-term goal is to identify potential therapeutic targets for prevention and treatment of inflammatory and infectious disease, cancer and neuronal degenerative disease.

University of Alabama at Birmingham (UAB)
Ph.D.

University of California, San Diego
Postdoctoral Fellow

NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta.
Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A. NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell. 2006 Feb 17; 21(4):467-80.
PMID: 16483929

The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis.
Tang F, Tang G, Xiang J, Dai Q, Rosner MR, Lin A. The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol. 2002 Dec; 22(24):8571-9.
PMID: 12446776

TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappa B: a central role for disruption of mitochondria.
Liu H, Ma Y, Pagliari LJ, Perlman H, Yu C, Lin A, Pope RM. TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappa B: a central role for disruption of mitochondria. J Immunol. 2004 Feb 01; 172(3):1907-15.
PMID: 14734776

Inactivation of BAD by IKK inhibits TNFa-induced apoptosis independently of NF-?B activation.
Yan J, Xiang J, Lin Y, Ma J, Zhang J, Zhang H, Sun J, Danial NN, Liu J, Lin A. Inactivation of BAD by IKK inhibits TNFa-induced apoptosis independently of NF-?B activation. Cell. 2013 Jan 17; 152(1-2):304-15.
PMID: 23332762

Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-a-induced JNK activation and inflammation.
Liu J, Yan J, Jiang S, Wen J, Chen L, Zhao Y, Lin A. Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-a-induced JNK activation and inflammation. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):191-6.
PMID: 22184250

ATIA: a link between inflammation and hypoxia.
Lin A. ATIA: a link between inflammation and hypoxia. Mol Cell. 2011 Jun 10; 42(5):557-8.
PMID: 21658597

Temporal control of TNFa signaling by Miz1.
Lin A. Temporal control of TNFa signaling by Miz1. Adv Exp Med Biol. 2011; 691:127-8.
PMID: 21153316

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell. 2009 Oct 09; 36(1):131-40.
PMID: 19818716

Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation.
Liu J, Zhao Y, Eilers M, Lin A. Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18279-84.
PMID: 19815509

Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis.
Tang F, Kokontis J, Lin Y, Liao S, Lin A, Xiang J. Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis. J Biol Chem. 2009 Nov 20; 284(47):32353-8.
PMID: 19723627

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