This paper discusses the mechanisms by which cellular signalling networks (specifically phosphotyrosine signaling) evolve through the development of novel and expanded families of modular domain proteins and the elaboration of connections between nodes. These changes underlie the variety of general and specific signalling networks that give rise to tissue-specific functions and increasingly complex developmental programs.
This paper was also the focus of the cover art which imagines the evolution of SH2 domain proteins as a tree watered by phosphotyrosine residues created by kinase action.
Philosophical Transactions of The Royal Society is the worlds oldest scientific journal. Established in 1665 it has remained in continuous publication ever since. Famous contributing authors include Isaac Newton, James Clerk Maxwell, Michael Faraday and Charles Darwin.