Marsha Rosner, Ph.D.


Yun, J., Frankenberger, C.A., Kuo, W.-L., Boelens, M.C., Eves, E.M., Cheng, N., Liang, H., Li, W.-H., Ishwaran, H., Minn, A.J., and Rosner, M.R., Signaling Pathway for RKIP and Let-7 Regulates and Predicts Metastatic Breast Cancer, EMBO J, 30(21):4500-14, (2011)

Shemon AN, Heil GL, Granovsky AE, Clark MM, McElheny D, Chimon A, Rosner MR, Koide S., Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands, PLoS One, 5(5):e10479. (2010)

Granovsky, A., Clark, MC, McElheny, D., Heil, G., Shiu, S-H, Hong, J., Liu, X., Kim, Y., Joachimiak, G., Joachimiak, A., Koide, S. andRosner, M.R. Raf Kinase Inhibitory Protein is Regulated via a Flexible Pocket and Novel Phosphorylation-dependent Mechanism, Mol. Cell Biol., 29(5), 1306-20.  (2009)

Shemon, A.N., Eves, E.M., Clark, M.C., Heil, G., Granovsky, A., Zeng, L., Imamoto, A.,Koide, S., and Rosner, M.R., Raf Kinase Inhibitory Protein Protects Cells against Locostatin-mediated Inhibition of Migration.  PLoS ONE4(6), e6028.  (2009)

Pavon-Eternod, Mariana, Gomes, S., Geslain, R., Dai, Q., Rosner, M.R., Pan, T., tRNA Over-expression in Breast Cancer and Functional Consequences, Nucleic Acids Research, doi:10.1093/nar/gkp787. (2009)

Doebele, R.C., Schulze-Hoepfner, F.T., Hong, J., Chlenski, A., Zeitlin, B.D., Goel, K., Gomes, S., Liu, Y., Abe, M., Nor, J.E., Lingen, M.W., and Rosner, M.R., A Novel Interplay Between Epac/Rap1 and MEK5/ERK5 Regulates Thrombospondin to Control Angiogenesis, Blood, 114(20):4592-600. (2009)

Cohen, E.E.W., Zhu, H., Lingen, M.W., Martin, L.E., Kuo, W.-L., Choi, E.A., Kocherginsky, M., Parker, J.S., Chung, C.H., and Rosner, M.R., A Feed Forward Loop Involving Protein Kinase C Alpha and MicroRNAs Regulates Tumor Cell Cycle, Cancer Res.  69(1) 65-74. (2009)  Cell Cycle Features – Invited.

Dangi-Garimella, S., Yun, J., Newman, M., Hammond, S. M., Eves, E. M., Minn, A. J., and Rosner, M. R. (2009).  Raf Kinase Inhibitory Protein suppresses a metastasis signaling cascade involving LIN28 and let-7.  EMBO J 28, 347-358.

Granovsky, A., Clark, M. C., McElheny, D., Heil, G., Shiu, S.-H., Hong, J., Liu, X., Kim, Y., Joachimiak, G., Joachimiak, A., Koide, S., and Rosner, M. R. (2009).  Raf Kinase Inhibitory Protein is regulated via a flexible pocket and novel phosphorylation-dependent mechanism.  Mol Cell Biol 29, 1306-1320.

Hong, J., Doebele, R. C., Lingen, M. W., Quilliam, L. A., Tang, W.-J., and Rosner, M. R. (2007). Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1.  J Biol Chem 282, 19781-19787.

Eves, E. M., Shapiro, P., Naik, K., Klein, U. R., Trakul, N., and Rosner, M. R. (2006). Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Mol Cell 23, 561-574.

Cohen, E. E., Lingen, M. W., Zhu, B., Zhu, H., Straza, M. W., Pierce, C., Martin, L. E., and Rosner, M. R. (2006). Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.  Cancer Res 66, 6296-6303.

Clark, M. C., McElheny, D. W., Wojcik, J., Kuritz, J., Rosner, M. R., and Koide, S. (2006). NMR assignment of rat raf kinase inhibitor protein. J Biomol NMR 36, Suppl 5:4.

Shen, Y., Joachimiak, A., Rosner, M. R., and Tang, W.-J. (2006). Structures of human Insulin-Degrading Enzyme reveal a new substrate recognition mechanism. Nature 443, 870-874.

Trakul, N., Menard, R. E., Schade, G. R., Qian, Z., andRosner, M. R. (2005). Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. J Biol Chem 280, 24931-24940.

Trakul, N., and Rosner, M. R. (2005). Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein. Cell Res 15, 19-23.

Corbit, K. C., Trakul, N., Eves, E. M., Diaz, B., Marshall, M., and Rosner, M. R. (2003). Activation of Raf-1 signaling by Protein Kinase C through a mechanism involving Raf Kinase Inhibitory Protein. J Biol Chem278, 13061-13068.


Eves, E., and Rosner, M.R., Raf Kinase Inhibitory Protein: A Signal Transduction Modulator and Metastasis Suppressor, Immunopathological Disease & Therapeutics, In press.  (2011)

Bevilacqua, E., Frankenberger, C., and Rosner, M.R., RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-associated Genes”,  Intl J of Breast Cancer, In press. (2011)

Eves, E.M. and Rosner, M.R., Mitogen-Activated Protein Kinase Regulation of the Mitotic Spindle Checkpoint. Rony Seger, ed. MAP Kinase Signaling Protocols, Second Edition, Part VI (31), 497-505.  (2010)