Anning Lin, Ph.D.


Representative publications (from total 80 publications; total citations >10,000)

Zhao Y, Lin Y, Zhang H, Manas A, Tang W, Zhang Y, Wu D, Lin A, Xiang J. Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching. Proceedings of the National Academy of Science USA, 112:9644-9649, 2015.

Yan J, Xiang J, Lin Y, Ma J, Zhang J, Zhang H, Sun J, Danial N, Liu J, Lin A.  Inactivation of the BH3-only protein BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation. Cell 152: 304-315, 2013.

Liu J, Yan J, Jiang S, Wen J, Cheng L, Zhao Y, and Lin A. Site-specific ubiquitination is required for relieving Miz1-mediated suppression on TNFa-induced JNK activation and inflammation. Proceedings of the National Academy of Science USA 109191-6, 2012.

Lin A. ATIA: A Link between Inflammation and Hypoxia. Molecular Cell 42:557-558,   2011.

Liu J, Zhao Y, Eilers M, and Lin A.  Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNFa-induced JNK activation.  Proceedings of the National Academy of Science USA 106:18279-18284, 2009.

Lin A. A Five-Year Itch in TNF Cytotoxicity: The Time Factor Determines JNK Action. Development Cell 10:277-278, 2006.

Liu J, Yang D, Minemoto Y, Leitges M, Rosner M.R, and Lin A. NF-kB via PKCd Promotes JNK Activation by UV. Molecular Cell 21:467-480, 2006.

Liu J and Lin A. Role of JNK activation in apoptosis: A double-edged sword. Cell Research 15:36-42, 2005.

Liu J, Minemoto Y, and Lin A. JNK1, but not JNK2, is essential for TNFa-induced c-Jun kinase activation and apoptosis. Molecular and Cellular Biology 24:10844-10856, 2004.

Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, Xiang J, and Lin A. JNK suppresses apoptosis via phosphorylation of the pro-apoptotic Bcl-2 family member BAD. Molecular Cell 13:32-9340, 2004.

Lin A. Activation of the JNK signaling pathway: Breaking the Brake of Apoptosis. BioEssays 25:17-24, 2003.

Lin A and Karin M. NF-kB in cancer: A marked target. Seminars in Cancer Biology 13:107-114, 2003.

Karin M and Lin A. NF-kB at the crossroad of life and death. Nature Immunology 3:221-227, 2002. (One of the most cited papers in the field, ISI, February 1st issue, 2003)

Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, and Lin A. Inhibition of JNK activation by NF-kB target genes. Nature 414:313-317, 2001. (News and Views, 414:265-266, 2001; Hot paper, The Scientist, 12:32-33, 2003)

Tang G, Yang J, Minemoto Y, and Lin A. Blocking caspase-3-mediated proteolysis of IKKb suppresses TNFa-induced apoptosis. Molecular Cell 8:1005-1016, 2001.

Purcell NH, Tang G, Yu C, Mercurio F, DiDonato JA, and Lin A. Activation of NF-kB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proceedings of National Academy of Science USA 98:6668-6673, 2001.

Minden A, Lin A, Claret FX, Abo A, and Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cde42Hs. Cell 81:1147-1157, 1995.

Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, and Karin M. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268:286-290, 1995.

Minden A, Lin A, McMahon M, Lange-Carter, C, Derifard B, Davis R, Johnson G, and Karin M. Bifurcation in Ras signaling: Raf-1 and MEKK-1 differentially activate ERK and JNK MAP kinases. Science 256:1719-1723, 1994.

Hibi M, Lin A, Smeal T, Minden A, and Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Gen.& Dev. 7:2135-2148, 1993.

Lin A, Frost J, Deng T, Smeal T, Al-Alawi N, Kikkawa U, Hunter T, Brenner A, and Karin M. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell 70:777-789, 1992