Akira Imamoto, D.D.S., Ph.D.


Seo, J.-H., Suenaga, A., Hatakeyama, M., Taiji, M., and Imamoto, A. Structural and functional basis of a role for CRKL in an FGF8-induced feedforward loop. Mol Cell Biol 29, 3076-3087 (2009). PMCID: PMC2681998

Guris, D. L., Duester, G. Papaioannou, V. E., and Imamoto, A. Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome. Dev Cell 10, 81-92 (2006). [PubMed] [FullText] Back-to-back with the article by Moon et al. (below) in the same issue

Moon, A. M., Guris, D. L., Seo, J.-H., Li, L., Talbot, A., Hammond, J., and Imamoto, A. Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndrome. Dev Cell 10, 71-80 (2006). [PubMed] [FullText] Back-to-back with the article by Guris et al. (above) in the same issue

Ballif, B. A., Arnaud, L., Arthur, W. T., Guris, D., Imamoto, A. and Cooper, J. A. Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol 14, 606-610 (2004). [PubMed] [FullText]

Duan, L. J., Imamoto, A. and Fong, G. H. Dual roles of the C-terminal Src kinase (Csk) during developmental vascularization. Blood 103, 1370-1372 (2004). [PubMed] [FullText]

Li, L., Guris, D. L., Okura, M. and Imamoto, A. Translocation of CrkL to focal adhesions mediates integrin-induced migration downstream of Src family kinases. Mol Cell Biol 23, 2883-2892 (2003). [PubMed] [FullText] Selected for the cover photo of the issue (see Images from the Lab)

Li, L., Okura, M. and Imamoto, A. Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion. Mol Cell Biol 22, 1203-1217 (2002). [PubMed] [FullText] Selected for the cover photo of the issue

Hagel, M., George, E. L., Kim, A., Tamimi, R., Opitz, S. L., Turner, C. E., Imamoto, A. and Thomas, S. M. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol 22, 901-915 (2002). [PubMed] [FullText]

Guris, D. L., Fantes, J., Tara, D., Druker, B. J. and Imamoto, A. Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome. Nature Genet 27, 293-298 (2001). [PubMed] [FullText] Featured in an accompanied News & Views article in the same issue

Zambrowicz, B. P., Imamoto, A., Fiering, S., Herzenberg, L. A., Kerr, W. G. and Soriano, P. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci U S A 94, 3789-3794 (1997). [PubMed] [FullText]

Thomas, S. M., Soriano, P. and Imamoto, A. Specific and redundant roles of Src and Fyn in organizing the cytoskeleton. Nature 376, 267-271 (1995). [PubMed] [FullText]

Imamoto, A., Soriano, P. and Stein, P. L. Genetics of signal transduction: tales from the mouse. Curr Opin Genet Dev 4, 40-46 (1994). [PubMed]

Imamoto, A. and Soriano, P. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell 73, 1117-1124. (1993) [PubMed] [FullText] Featured in an accompanied Minireview article in the same issue