"Discovery is our Business." Charles Huggins (Nobel Prize Laureate)

Welcome to the Ben May Department

All were hooded at our Divisional Academic Ceremony where Kay Macleod served as the student-selected Faculty Marshall. Lauren Drake, Marina Sharifi, Erin Mowers, Aparajita Hoskote Chourasia, Michelle Beaton.(L to R)

Five PhDs awarded in the Ben May Department for Cancer Research

Faces of Ben May Dept. of Cancer Research View the Gallery

Faces of BMDCR

Biography of Charles Brenton Huggins

"With blood on the hands I have chance, seated at the desk I have no chance." Charles Brenton Huggins (Nobel Prize Laureate) Click Here for Biography of Dr. Huggins

Biography of Charles Brenton Huggins

Welcome to the Ben May Department for Cancer Research

Our vision is a future where cancer is eliminated by total cure or managed by chronic treatment that enables a high quality of life.

The mission of the Ben May Department is embodied in the motto of our founder, the late Nobel Prize winner Charles Huggins: "Discovery is our Business."  In that spirit of discovery, our researchers are pushing the boundaries of understanding and challenging the assumptions that often impede progress.  We believe the first step toward preventing or curing cancer is basic research on the intricacies of the human body and the molecular, cellular, and genetic events that lead to cancer.  Advances in our fundamental understanding of cancer can then be translated into better methods of prevention and diagnosis.

Latest News and Announcements

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Will High-Tech Skin Put an End to Needle Sticks for Diabetes?

Dr. Xiaoyang Wu led a team that used stem cells and the gene-editing technique CRISPR to create skin cells that emit fluorescent light in a particular pattern as blood glucose levels rise.

Full article here https://www.nbcnews.com/mach/science/will-high-tech-skin-put-end-needle-...

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CRISPR Gene Therapy via Skin Grafts Treats Obesity and Diabetes in Mice

Xiaoyang Wu

Genetically engineered skin cells grafted onto mice can treat the animals’ diabetes and obesity, according to new research published August 2, 2017 in Cell Stem Cell.

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Thomas F. Gajewski has been named the first AbbVie Foundation Professor of Cancer Immunotherapy in Pathology.

Gajewski’s team members study ways to overcome a tumor’s ability to elude the immune system, with a focus on drugs that help the immune system, especially T cells, gain access to tumor sites. They have discovered genetic clues that correlate with response versus resistance, enabling them to identify new therapies to overcome resistance and expand efficacy. They also discovered that certain components of the gut microbiota—microbes that live in a patient’s digestive tract—could stimulate the immune system to attack tumor cells.

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Prof. Thomas Gajewski honored for pioneering cancer research

Outstanding Investigator Award provides $4.2 million grant over seven years

The National Cancer Institute, a branch of the National Institutes of Health, has awarded an Outstanding Investigator Award to Prof. Thomas Gajewski. The award supports scientists who demonstrate remarkable productivity in cancer research and guarantees $600,000 in direct costs per year for seven years.

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Geoffrey Greene, Ph. D Named AAAS Fellow

Geoffrey Greene, the Virginia and D. K. Ludwig Professor and chair of the Ben May Department for Cancer Research: For distinguished contributions to the field of steroid hormone action and breast cancer, particularly for the development of estrogen and progesterone receptor antibodies.


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Workshops Break Down Research Silos, Form New Collaborations

More than 20 researchers and UChicago’s Executive Vice President for Research, Innovation and National Laboratories recently came together to share their work, form new collaborations, and address shared hurdles at a multidisciplinary workshop on imaging and noise.

“This is team science, wildly transdisciplinary, and fun,” said Julian Solway, MD, Director of the University of Chicago Institute for Translational Medicine (ITM) that co-organized the July 29 event. “We’re finding that we have commonalities and synergies that we hadn’t recognized.”

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Steroid receptor crosstalk informs therapies for breast cancer treatment

Geoffrey Greene, Ph.D. published in Scientific Advances

One of the first clues pathologists look for in tissue from a newly diagnosed breast cancer patient is the estrogen receptor, a nuclear protein that converts hormonal messages in the bloodstream into instructions for the cell about how to behave. They also look for the presence of progesterone receptors, primarily to confirm that the estrogen receptor is active.

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Stopping cancer in its tracks

Disrupting autophagy, a cellular housekeeping process, limits cancer spread

Researchers from the University of Chicago have shown that inhibiting autophagy, a self-devouring process used by cells to degrade large intra-cellular cargo, effectively blocks tumor cell migration and breast cancer metastasis in tumor models. In a study, published May 12, 2016, in the journal Cell Reports, they demonstrate that the process is essential for tumor metastasis and describe the mechanisms that connect autophagy to cell migration.

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